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jos.debraekeleer@wiv-isp.be |
GIGA-RESEARCH, UNIVERSITY OF LIÈGE CELLULAR AND MOLECULAR PHYSIOLOGY B34- 2nd Floor 4000 LIEGE PHONE: +32 4 366 3708 OR +32 4 366 4284 FAX: +32 4 366 4285 Doctoral/Post-doctoral fellowship in Respiratory Immunology The laboratory of Cellular and Molecular Physiology (Interdisciplinary group of applied Genoproteomics (GIGA) – University of Liege, Belgium) is looking for : (M/F) Masters or PhDs in Medicine, Veterinary Medicine, Science, Biomedical Science or Pharmaceutical Science (or equivalent) We are looking for highly motivated PhD students and post-docs with a strong interest in fundamental immunology. We offer a stimulating and interactive research environment, state of the art facilities, and a competitive salary. Job description: - Full time doctoral or post-doctoral position. - Post-doc: 12 months Fellowship renewable up to 4 years. - PhD student: 24 months Fellowship renewable once. - Starting date: June-September 2010 - Research project : Cellular and molecular mechanisms of asthma. Eligibility requirements for PhD students: _ Strong interest in Immunology _ Good knowledge of English (written) _ Willing to work with mouse models of asthma Eligibility requirements for Post-docs: _ Strong interest in Immunology _ Know-how in routine biotechnology techniques such as cell culture, ELISA, western blotting, PCR, … _ Experience in mouse experimentation and FELASA C qualification (or equivalent) is a plus _ Experience in flow cytometry and FACS is a plus _ Good knowledge of english (spoken and written) Recent publications from our lab: Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. 2009. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest 119:3723-3738. Henry, E., Desmet, C.J., Garze, V., Fievez, L., Bedoret, D., Heirman, C., Faisca, P., Jaspar, F.J., Gosset, P., Jacquet, A.P.A., et al. 2008. Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma. J Immunol 181:7230-7242. Please send your letter of application as well as your curriculum vitae to : - Prof. F. Bureau : fabrice.bureau@ulg.ac.be - Phone: + 32 4 366 4284 Un(e) scientifique motivé(e) pour un mandat de chercheur post-doctoral Diplôme et qualifications souhaitées : - Docteur en sciences biomédicales, biologie, ou pharmacie ; - Expérience en cytométrie de flux, biologie moléculaire et expérimentation animale constituent des atouts. Projets de recherches du groupe: - Mécanismes cellulaires et moléculaires régulant la production et le transport transépithélial d’IgA dans l’asthme et la broncho-pneumopathie chronique obstructive : analyses de l’expression tissulaire du récepteur pIgR ; régulation de l’expression du pIgR et de sa transcytose en co-cultures de cellules épithéliales bronchiques polarisées (en interface air-liquide) avec des neutrophiles ; - Régulation via le Fc-récepteur des cellules dendritiques de patients allergiques : analyses de l’expression de surface de marqueurs dendritiques ; co-cultures autologues et allogéniques avec lymphocytes CD4+ ; signalisation intracellulaire ; développement de cultures de cellules dendritiques des muqueuses ; - Susceptibilité de souris pIgR KO à développer une pathologie respiratoire chronique (asthme, BPCO) : modèle de sensibilisation au DPT ou d’exposition aux endotoxines. Date et financement : financement à solliciter auprès des grands fonds (FNRS, FSR) - pour mandat au 01/10/2010 Pour obtenir plus d’informations ou poser votre candidature (incluant CV et 2 personnes de référence) : Pr. Charles PILETTE Pneumologie, Cliniques St Luc & Université catholique de Louvain E-mail : charles.pilette@uclouvain.be Tel. 02/764 5491 ou 02/764 2832 GlaxoSmithKline Biologicals (GSK Bio), one of the world’s leading vaccine manufacturers, is located in Rixensart and Wavre, Belgium. Belgium is the centre of all GSK’s activities in the filed of vaccine research, development and production. GSK Biologicals employs more than 1000 research scientists who are devoted to discovering new vaccines and developing more cost-effective and convenient combination products to prevent infections that cause serious medical problems worldwide. GSK Biologicals employs more than 4500 employees in Belgium (more than 6000 worldwide) Responsibilities: Human Cell-Mediated Immunity Technology Platform: Manage, prioritise activities and interact efficiently with internal and external partners for delivering Project Milestones on time and with quality required to R&D and GVD, in line with GSKBio priorities Key Responsibilities: - Ensure state of the art human cell-mediated immunity technological development in line with R&D and GSK Bio Strategy as well as technological watch. - Ensure optimal use of human cell-mediated immunity technologies in human clinical trial (GLP-like laboratory activity) - Provide expertise analysis of immunogenicity results generated in human clinical trial and discuss their implication in the context of microbiology and protection against infectious diseases internally and with authorities. - Ensure optimal R&D milestones achievement for priority vaccine project - Establish and manage relationships with external collaborators/laboratories involved in the generation of cell-mediated immunogenicity data in human clinical trials Specific deliverables to be indicated Human cellular Immunology group 1. Collaborate with research groups to identify and set-up innovative cell-mediated immunity read-out for human phase I clinical trial 2. Develop robustness of new cell-mediated immunity read-out for human phase I clinical trial. This can be done inside R&D or in collaboration with an outside collaborator. 3. Identify and propose relevant cell-mediated immunity read-out for specific human phase I/II clinical trial 4. Perform cell-mediated immunity read-out for human phase I/II clinical trial (GLP-like laboratory activity). This can be done inside R&D or in collaboration with an outside collaborator. 5. Deliver human clinical trial immunogenicity data to the appropriate department for data analysis. 6. Present cell-mediated immunity results as well as their implications in the context of transversal knowledge and/ or specific projects 7. Budget management 8. Archive and protect information according to global research standard and in collaboration with CIP and RA and QA ensuring patent watch. Manage staff and collaborators 1. Lead, coach, motivate and ensure harmonious professional development of staff under responsibility 2. Provide knowledge and insight to the teams on technical activities and maintain knowledge of leading edge technology and research 3. Total headcount: 4 scientists and 9 technicians (1 direct report) Profile: Has recognised expertise in specific area, internally as well as internationally: - Specialised in depth knowledge in Immunology, Immuno-monitoring, Immuno-pathology. - Clear understanding of flow cytometry, cell culture technology, mononuclear cells purification and cultivation, immunofluorescence, cell sorting. - Good knowledge in immunomolecular biology and microbiology - Good knowledge and understanding of GSK Bio global scientific and product development strategy and objectives. Integrate this knowledge in decisions and recommendations - Good knowledge of internal as well as external networks within R&D and GVD matrix organisation - Good Knowledge of GLP guidelines for clinical laboratory activity If you are interested in this role and you have the necessary qualifications please apply for this vacancy via the hyperlink URL: www.gsk-bio.com At GSK we provide a supportive working environment, and a range of development challenges and opportunities. We also offer competitive benefits and compensation packages designed to attract and to retain the very best. Thank you for taking the time and effort to apply for this role. Please note that we will only contact you again if you are invited to interview. GSK is proud to promote an open culture, encouraging people to be themselves and giving their ideas a chance to flourish. GSK is an equal opportunity employer GlaxoSmithKline Biologicals (GSK Biologicals) is one of the world’s leading vaccine manufacturers. The company is located in Rixensart (Belgium) and is the centre of all GlaxoSmithKline’s activities in the field of vaccine research, development and production. GSK Biologicals employs over 5 000 people in Belgium (over 8 000 worldwide), of whom more than 1 500 are passionate scientists devoted to discovering innovative vaccines and developing cost-effective and convenient combination products that contribute to the health and well-being of billions of people, in every generation around the world. 21194 - Scientist Bacterial Infectious Disease.doc |
